¡Oferta! A PHARMACOLOGY PRIMER

A PHARMACOLOGY PRIMER

Autor(es): KENAKIN
Editorial: ACADEMIC PRESS
Fecha de publicación: junio 2014
Nº de edición:
Nº de páginas: 456
Medidas: 22x29x2 cms

9780124076631

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KeyFeatures

·                    Highlights changes surrounding the strategy ofdrug discovery to provide you witha comprehensive reference featuring advances in the methods involvedin lead optimization and more effective drug discovery

·                    Includes a new chapter on data-driven drug discoveryin terms of the optimal design of pharmacologicalexperiments to identify mechanism of action of new molecules

·                    Illustrates the application of rapidinexpensive assays to predict activity in the therapeutic setting, showing dataoutcomes and the limitations inherentin interpreting this data

Description

A Pharmacology Primer: Techniques for MoreEffective and Strategic Drug Discovery,4th Edition features the latest ideas and research about theapplication of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Writtenby well-respected pharmacologist, Terry P. Kenakin,this primer is anindispensable resource for all thoseinvolved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery,biased signaling,structure-based drugdesign, drug activityscreening, drug development(including pharmacokineticsand safety Pharmacology),and much more. With more color illustrations, examples,and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.

Readership

Industry, academic and regulatory scientists involved in drug discovery or pharmacologic research, medicinal chemists and industrial chemists; graduate and post-doctoral students in pharmacology and pharmaceuticalscience programs

 

TABLE OFCONTENTS

Chapter 1 - What is Pharmacology?
Chapter 2 - How Different Tissues Process Drug ResponseChapter 3 - Drug Receptor Theory
Chapter 4 - Pharmacological Assay Formats: BindingChapter 5 - Agonists: The Measurement of Affinity and Efficacy in Functional Assays
Chapter 6 - Orthosteric Drug Antagonism
Chapter 7 - Allosteric DrugInteractions
Chapter 8 - Drug DiscoveryChapter 9 - Drug Development: Pharmacokinetics and Safety Pharmacology
Chapter 10 - Target-and System-basedStrategies for Drug DiscoveryChapter 11 - Lead Optimization: Data-Driven Analysis
Chapter 12 - Statistics and Experimental Design
Chapter 13 - Selected Pharmacological MethodsChapter 14 - Exercises in Pharmacodynamics and PharmacokineticsGlossary of Pharmacological Terms
Appendices
Statistical Tables
MathematicalFitting Functions

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A PHARMACOLOGY PRIMER

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A PHARMACOLOGY PRIMER

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