HARRISON'S MANUAL OF MEDICINE

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All theauthority of the most trusted brand in medical content in a convenient,portable guide
The Harrisons Manual, derived from most clinically salient content featured in Harrison'sPrinciples of Internal Medicine, 20th Edition, delivers numerous clinicalalgorithms in one practical, portable resource.  The Manual also includes abundant quick reference tables, plus concise textproviding rapid access tobedside information when decisions need to be made quickly. This full color summary guide covers all diseases andconditions commonly seen in inpatient generalmedicine, so you can be sureto find invaluable content directly to your workflowand practice.

The 20th edition has been updated to reflectthe latest clinical developments inmedicine. 
The Manual trulymakes it easy to find what you need at the point of care. The easy-to-navigate chapters cover symptoms/signs, medical emergencies, specific diseases, and care ofthe hospitalized patient, with a particular focus on:

Etiology andEpidemiology
Clinically Relevant Pathophysiology
Signs and Symptoms
Differential Diagnosis
Physical and Laboratory Findings
Therapeutics
Practice Guidelines, and more

TABLE OF CONTENTS

Contributors 
Preface 
Acknowledgments 
SECTION 1 Care of the Hospitalized Patient 
1 Electrolytes 
2 Acid-Base Disorders 
3 Diagnostic Imaging in InternalMedicine 
4 Procedures Commonly Performedby Internists 
5 Principles of Critical Care Medicine 
6 Pain and Its Management 
7 Assessment of Nutritional Status 
8 Enteral and Parenteral Nutrition 
9 Transfusion and Pheresis Therapy 
10 Palliative and End-of-LifeCare 
SECTION 2 Medical Emergencies 
11 Cardiovascular Collapse andSudden Death 
12 Shock 
13 Narcotic Overdose 
14 Sepsis and Septic Shock 
15 Acute Pulmonary Edema 
16 Acute RespiratoryDistress Syndrome 
17 Respiratory Failure 
18 Confusion, Stupor, and Coma 
19 Stroke 
20 Subarachnoid Hemorrhage 
21 Increased Intracranial Pressure and HeadTrauma 
22 Spinal Cord Compression 
23 Hypoxic-Ischemic Encephalopathy 
24 Status Epilepticus 
25 Diabetic Ketoacidosis and Hyperosmolar Coma 
26 Hypoglycemia 
27 Oncologic Emergencies 
28 Anaphylaxis 
29 Bites, Venoms, Stings, and Marine Poisonings 
SECTION 3 Common Patient Presentations 
30 Fever, Hyperthermia, and Rash 
31 Generalized Fatigue 
32 Unintentional Weight Loss 
33 Chest Pain 
34 Palpitations 
35 Dyspnea 
36 Cyanosis 
37 Cough and Hemoptysis 
38 Edema 
39 Abdominal Pain 
40 Nausea, Vomiting, and Indigestion 
41 Dysphagia 
42 Diarrhea, Malabsorption,and Constipation 
43 Gastrointestinal Bleeding 
44 Jaundice and Evaluation of Liver Function 
45 Ascites 
46 Lymphadenopathy and Splenomegaly 
47 Anemia and Polycythemia 
48 Azotemia and Urinary Abnormalities 
49 Pain and Swelling of Joints 
50 Back and Neck Pain 
51 Headache 
52 Syncope 
53 Dizziness and Vertigo 
54 Acute Visual Loss and Double Vision 
55 Weakness and Paralysis 
56 Tremor and Movement Disorders 
57 Aphasia 
58 Sleep Disorders 
SECTION 4 Otolaryngology 
59 Sore Throat, Earache, and UpperRespiratory Symptoms 
SECTION 5 Dermatology 
60 General Examination of the Skin 
61 Common Skin Conditions 
SECTION 6 Hematology and Oncology 
62 Examination of Blood Smears andBone Marrow 
63 Red Blood Cell Disorders 
64 Leukocytosis and Leukopenia 
65 Bleeding and Thrombotic Disorders 
66 Myeloid Leukemias, Myelodysplasia, and Myeloproliferative Syndromes 
67 Lymphoid Malignancies 
68 Skin Cancer 
69 Head and Neck Cancer 
70 Lung Cancer 
71 Breast Cancer 
72 Tumors of the Gastrointestinal Tract 
73 Genitourinary Tract Cancer 
74 Gynecologic Cancer 
75 Tumors of the Nervous System 
76 Prostate Hyperplasia and Carcinoma 
77 Cancer of Unknown Primary Site 
78 Paraneoplastic EndocrineSyndromes 
79 Neurologic ParaneoplasticSyndromes 
SECTION 7 Infectious Diseases 
80 Growing Threats in Infectious Disease 
81 Infections Acquired in Health Care Facilities 
82 Infections in the Immunocompromised Host 
83 Infective Endocarditis 
84 Intraabdominal Infections 
85 Infectious Diarrheas and Bacterial Food Poisoning 
86 Sexually Transmitted and Reproductive Tract Infections 
87 Infections of the Skin, Soft Tissues, Joints, and Bones 
88 Pneumococcal Infections 
89 Staphylococcal Infections 
90 Streptococcal/EnterococcalInfections, Diphtheria, and Infections Caused by Other Corynebacteria and Related Species 
91 Meningococcal and Listerial Infections 
92 Infections Caused byHaemophilus, Bordetella, Moraxella,and HACEK Group Organisms 
93 Diseases Caused by Gram-Negative EntericBacteria and Pseudomonads 
94 Infections Caused by Miscellaneous Gram-Negative Bacilli 
95 Anaerobic Infections 
96 Nocardiosis, Actinomycosis,and Whipples Disease 
97 Tuberculosis and Other Mycobacterial Infections 
98 Lyme Disease and Other NonsyphiliticSpirochetal Infections 
99 Rickettsial Diseases 
100 Mycoplasma pneumoniae, Legionella Species, and Chlamydia pneumoniae 
101 Chlamydia trachomatis and Chlamydia psittaci 
102 Infections with Herpes Simplex Virus, Varicella-Zoster Virus, Cytomegalovirus,Epstein-Barr Virus, andHuman Herpesvirus Types 6,7, and 8 
103 Influenza and OtherViral Respiratory Diseases 
104 Rubeola, Rubella, Mumps, and ParvovirusInfections 
105 Enterovirus Infections 
106 Insect- andAnimal-Borne Viral Infections 
107 HIV Infection and AIDS 
108 Pneumocystis Pneumonia,Candidiasis, and Other Fungal Infections 
109 Overview of Parasitic Infections 
110 Malaria, Toxoplasmosis, Babesiosis,and Other Protozoal Infections 
111 Helminthic Infections and Ectoparasite Infestations 
SECTION 8 Cardiology 
112 Physical Examination of the Heart 
113 Electrocardiography 
114 Noninvasive Examinationof the Heart 
115 Congenital Heart Disease in the Adult 
116 Valvular Heart Disease 
117 Cardiomyopathies and Myocarditis 
118 Pericardial Disease 
119 Hypertension 
120 Metabolic Syndrome 
121 ST-Segment Elevation Myocardial Infarction 
122 Unstable Angina andNon-ST-Elevation Myocardial Infarction 
123 Chronic Stable Angina 
124 Bradyarrhythmias 
125 Tachyarrhythmias 
126 Heart Failure and Cor Pulmonale 
127 Diseases of the Aorta 
128 Peripheral Vascular Disease 
129 Pulmonary Hypertension 
SECTION 9 Pulmonology 
130 Diagnostic Proceduresin Respiratory Disease 
131 Asthma 
132 Environmental Lung Diseases 
133 Chronic Obstructive Pulmonary Disease 
134 Pneumonia, Bronchiectasis,and Lung Abscess 
135 Pulmonary Thromboembolismand Deep-Vein Thrombosis 
136 Interstitial Lung Disease 
137 Diseases of the Pleura 
138 Diseases of the Mediastinum 
139 Disorders of Ventilation 
140 Sleep Apnea 
SECTION 10 Nephrology 
141 Acute Renal Failure 
142 Chronic Kidney Disease and Uremia 
143 Dialysis 
144 Renal Transplantation 
145 Glomerular Diseases 
146 Renal Tubular Disease 
147 Dysuria, Urinary Tract Infections, Bladder Pain, andInterstitial Cystitis 
148 Nephrolithiasis 
149 Urinary Tract Obstruction 
SECTION 11 Gastroenterology 
150 Peptic Ulcer and Related Disorders 
151 Inflammatory Bowel Diseases 
152 Colonic and Anorectal Diseases 
153 Cholelithiasis, Cholecystitis,and Cholangitis 
154 Pancreatitis 
155 Acute Hepatitis 
156 Chronic Hepatitis 
157 Cirrhosis and Alcoholic Liver Disease 
158 Portal Hypertension 
SECTION 12 Allergy, Clinical Immunology, and Rheumatology 
159 Diseases of Immediate-Type Hypersensitivity 
160 Primary Immune Deficiency Diseases 
161 Systemic Lupus Erythematosus 
162 Rheumatoid Arthritis 
163 The Spondyloarthritides 
164 Other Connective Tissue Diseases 
165 Vasculitis 
166 Osteoarthritis 
167 Gout, Pseudogout, and Related Diseases 
168 Other Musculoskeletal Disorders 
169 Sarcoidosis 
170 Amyloidosis 
SECTION 13 Endocrinology and Metabolism 
171 Disorders of the Anterior Pituitary and Hypothalamus 
172 Diabetes Insipidus and Syndrome of InappropriateAntidiuretic Hormone 
173 Thyroid Gland Disorders 
174 Adrenal Gland Disorders 
175 Obesity 
176 Diabetes Mellitus 
177 Disorders of the Male Reproductive System 
178 Disorders of the Female ReproductiveSystem 
179 Hypercalcemia and Hypocalcemia 
180 Osteoporosis and Osteomalacia 
181 Hypercholesterolemia andHypertriglyceridemia 
182 Hemochromatosis, Porphyrias,and Wilsons Disease 
SECTION 14 Neurology 
183 The Neurologic Examination 
184 Seizures and Epilepsy 
185 Alzheimers Disease and Other Dementias 
186 Parkinsons Disease 
187 Ataxic Disorders 
188 ALS and Other Motor Neuron Diseases 
189 Autonomic Nervous System Disorders 
190 Trigeminal Neuralgia, BellsPalsy, and Other Cranial NerveDisorders 
191 Spinal Cord Diseases 
192 Multiple Sclerosis 
193 Neuromyelitis Optica 
194 Acute Meningitis and Encephalitis 
195 Chronic and Recurrent Meningitis 
196 Peripheral Neuropathies,Including Guillain-Barré Syndrome 
197 Myasthenia Gravis 
198 Muscle Diseases 
SECTION 15 Psychiatry and Substance Abuse 
199 Psychiatric Disorders 
200 Psychiatric Medications 
201 Eating Disorders 
202 Alcohol Use Disorder 
203 Narcotic Abuse 
204 Cocaine and Other Commonly Used Drugs 
SECTION 16 Disease Prevention and Health Maintenance 
205 Routine Disease Screening 
206 Vaccines 
207 Cardiovascular Disease Prevention 
208 Prevention and Early Detection of Cancer 
209 Smoking Cessation 
210 Womens Health 
SECTION 17 Adverse Drug Reactions 
211 Adverse Drug Reactions 
Index