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TheInternational Textbook of Diabetes Mellitus has been a successful,well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedicand international in scope, the textbook covers all aspects of diabetesensuring a truly multidisciplinary and global approach. Sections coveredinclude epidemiology, diagnosis, pathogenesis, management and complications ofdiabetes and public health issues worldwide. It incorporates a vast amount ofnew data regarding the scientific understanding and clinical management of thisdisease, with each new edition always reflecting the substantial advances inthe field. Whereas other diabetes textbooks are primarily clinical with lessfocus on the basic science behind diabetes, ITDM's primary philosophy has alwaysbeen to comprehensively cover the basic science of metabolism, linking thisclosely to the pathophysiology and clinical aspects of the disease.
Edited byfour world-famous diabetes specialists, the book is divided into 13 sections,each section edited by a section editor of major international prominence. Aswell as covering all aspects of diabetes, from epidemiology and pathophysiologyto the management of the condition and the complications that arise, thisfourth edition also includes two new sections on NAFLD, NASH andnon-traditional associations with diabetes, and clinical trial evidence indiabetes.
This fourthedition of an internationally recognised textbook will once again provide allthose involved in diabetes research and development, as well as diabetesspecialists with the most comprehensive scientific reference book on diabetesavailable.
Contributors
Preface
VOLUME 1
SECTION 1:EPIDEMIOLOGY
1Classification of diabetes mellitus and other categories of glucose intolerance
Dianna J. Magliano, Paul Zimmet & Jonathan Shaw
2Epidemiology and risk factors for type 1 diabetes mellitus
Andrea K. Steck & Marian J. Rewers
3Epidemiology and geography of type 2 diabetes mellitus
Qing Qiao, Desmond E. Williams, Giuseppina Imperatore, K.M. Venkat Narayan& Jaakko Tuomilehto
SECTION 2:PHYSIOLOGY OF PANCREATIC FUNCTION
4Development and maintenance of the islet ß cell
Teresa L. Mastracci, Raghavendra G. Mirmira & Ryan M. Anderson
5 Pancreaticmorphology in normal and diabetic states
Rebecca L. Hull & Steven E. Kahn
6 Insulingene expression and biosynthesis
Vincent Poitout, Roland Stein & Christopher J. Rhodes
7 ß-Cellbiology of insulin secretion
Susumu Seino, Tadao Shibasaki & Kohtaro Minami
8 Normal ß-cell function
Andrea Natali, Stefano Del Prato & Andrea Mari
9Neuropeptides and islet hormone secretion
Bo Ahrén
10Biosynthesis, secretion, and action of glucagon
Pierre J. Lefèbvre
11 Incretinphysiology in health and disease
Juris J. Meier & Michael A. Nauck
SECTION 3: NORMAL PHYSIOLOGY OF INSULIN ACTION
12Mechanisms of insulin signal transduction
Paul R. Langlais, Lawrence J. Mandarino & W. Timothy Garvey
13Regulation of glucose metabolism in liver
Shawn C. Burgess
14 Insulinactions in vivo: glucose metabolism
Ele Ferrannini & Ralph A. DeFronzo
15 Measuringinsulin action in vivo
Richard N. Bergman & Marilyn Ader
16 Proteinmetabolism in health and diabetes
Elena Volpi & Jared Dickinson
17 Lipid andlipoprotein metabolism, hypolipidemic agents, and therapeutic goals
Gissette Reyes-Soffer & Henry N. Ginsberg
18Metabolomics: applications in type 2 diabetes mellitus and insulin resistance
Sean H. Adams & John W. Newman
SECTION 4:NAFLD, NASH AND NON-TRADITIONAL ASSOCIATIONS WITH DIABETES
19Pathogenesis of nonalcoholic fatty liver disease (NAFLD)
Hannele Yki-Järvinen
20 Treatmentof nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis(NASH)
Fernando Bril, Kwame Ntim, Romina Lomonaco & Kenneth Cusi
21 Type 2diabetes and cancer
Emily Jane Gallagher, Ruslan Novosyadlyy & Derek LeRoith
22 Diabetesand sleep apnea
Abd A. Tahrani
SECTION 5:PATHOGENESIS
23 Theinsulin resistance syndrome
Naveed Sattar, Paul Welsh & David Preiss
24 ß-Cellmass and function in human type 2 diabetes
Piero Marchetti & Ele Ferrannini
25Pathogenesis of type 2 diabetes mellitus
Ralph A. DeFronzo
26 Thegenetics of type 2 diabetes
Emma Ahlqvist & Leif Groop
27 Glucosetoxicity
Hannele Yki-Järvinen & Donald A. McClain
28 Monogenicdisorders of the ß cell
Ali J. Chakera & Andrew T. Hattersley
29Immunopathogenesis of type 1 diabetes in Western society
Alberto Pugliese
30 Moleculargenetics of type 1 diabetes
M. Ann Kelly, Simon D. Rees, Anthony H. Barnett & Stephen C. Bain
SECTION 6:OBESITY
31 Therelationship between obesity and type 2 diabetesthe role of gut factors
Daniel S. Hsia & William T. Cefalu
32 The roleof energy metabolism in the regulation of energy balance
Charmaine S. Tam & Eric Ravussin
33 Treatmentof obesity: lifestyle and pharmacotherapy
Arne Astrup
34 Treatmentof obesity: bariatric surgery
Karl J. Neff, Ele Ferrannini & Carel W. le Roux
35 Animalmodels of obesity and type 2 diabetes
David A. York, Mie Jung Park-York & Timothy Gilbertson
36 The roleof the hypothalamus in the maintenance of energy balance and peripheral glucosecontrol
Luis Varela & Tamas L. Horvath
SECTION 7:CLINICAL TRIAL EVIDENCE IN DIABETES
37Prevention of type 1 diabetes
Jay S. Skyler
38Prevention of type 2 diabetes
Thomas Yates & Melanie Davies
39Prevention of diabetic microvascular complications
Alice P.S. Kong, Nicola Brown & Juliana C.N. Chan
VOLUME 2
SECTION 8: MANAGEMENT OF DIABETES: DIET, EXERCISE AND DRUGS
40 Dietarymanagement of diabetes mellitus in Europe and North America
Jim I. Mann & Alexandra Chisholm
41 Exercise
Henrik Galbo & Erik A. Richter
42Sulfonylureas and meglitinides: insights into physiology and translationalclinical utility
Harold E. Lebovitz & Arne Melander
43 Metforminand other biguanides: pharmacology and therapeutic usage
Susan L. Samson & Alan J. Garber
44 PPARagonists in the treatment of diabetes
Sunder Mudaliar & Robert R. Henry
45 a-Glucosidaseinhibitors
Josée Leroux-Stewart, Rémi Rabasa-Lhoret & Jean-Louis Chiasson
46Combination therapy in type 2 diabetes mellitus
Muhammad Abdul-Ghani, Ralph A. DeFronzo & R. Eldor
47 New drugsfor the treatment of diabetes mellitus
Clifford J. Bailey
48 Incretin-based therapies
Michael A. Nauck & Juris J. Meier
49 Insulin pumps
Dace L. Trence & Irl B. Hirsch
50Innovative therapies in diabetes: colesevelam and bromocriptine
Shamsa Ali & Vivian Fonseca
SECTION 9:MANAGEMENT OF DIABETES: MONITORING AND OTHER INTERVENTIONS
51Implantable pumps and artificial and bio-artificial pancreas system
William Tamborlane & Miladys M. Palau-Collazo
52 Pancreasand islet transplantation
R. Paul Robertson
53Hypoglycemia and other complications of insulin therapy
Stephanie A. Amiel
54 Diabetic ketoacidosis and hyperosmolar state
Abbas E. Kitabchi, Guillermo E. Umpierrez & Mary Beth Murphy
SECTION 10:MANAGEMENT OF DIABETES: GLUCOSE AND LIPID MONITORING, SPECIFIC SUBGROUPS
55 Type 2diabetes in obese adolescents: pathophysiology and treatment
Grace Kim & Sonia Caprio
56 Diabetes in pregnancy
Yoel Toledano, Eran Hadar & Moshe Hod
57 Aging anddiabetes mellitus
Hermes Florez, Jorge Ruiz & Medha Munshi
58 Psychologicalproblems and management of patients with diabetes mellitus
Alan M. Delamater, Ashley Marchante & Jennifer Hernandez
59 Glycatedhemoglobin, serum proteins, and other markers as tools for monitoring
Susan M. Gerber, Douglas Stickle, Intekhab Ahmed & Serge Jabbour
SECTION 11:COMPLICATIONS OF DIABETES: GENERAL AND MICROVASULAR
60Pathogenesis of diabetic microvascular complications
Josephine M. Forbes & Brooke Harcourt
61 Diabeticretinopathy and other ocular complications
Gavin S. Tan & Tien Yin Wong
62 Diabeticnephropathy
George Jerums, Elif I. Ekinci, Erosha Premaratne, Scott T. Baker, SiannaPanagiotopoulos & Richard J. MacIsaac
63 Pathologyof human diabetic neuropathy
M. Mojaddidi, A.K. Sharma & Ravaz A. Malik
64 Autonomicneuropathy
Chinmay S. Marathe, Liza Phillips & Michael Horowitz
65Connective tissue disorders in diabetes
Arlan L. Rosenbloom
66 Thediabetic foot
Frank L. Bowling & Andrew J.M. Boulton
67 Erectiledysfunction in diabetes mellitus
Michael H. Cummings & Rajesh Rajendran
68Periodontal disease and diabetes mellitus
Wenche S. Borgnakke & Robert J. Genco
SECTION 12:COMPLICATIONS OF DIABETES: MACROVASCULAR
69Epidemiology of macrovascular disease and hypertension in diabetes mellitus
Jaakko Tuomilehto, Daiva Rastenyte, Qing Qiao & Dimitrije Jakovljevic
70Atherogenesis, coronary heart disease and insulin resistance syndrome indiabetes
Barak Zafrir & Jorge Plutzky
71Endothelial function and metabolic syndrome
Xinpu Chen & Sridevi Devaraj
72Haemostatic abnormalities in diabetes mellitus
R.A. Ajjan & Peter J. Grant
73 Clinicalfeatures and treatment of coronary heart disease in diabetes
Eberhard Standl, Michael Erbach, Markolf Hanefeld, Oliver Schnell, BerndStratmann & Diethelm Tschoepe
74 Arterialhypertension in diabetes: etiology and treatment
Colleen Flynn & George Bakris
75Peripheral vascular and cerebrovascular disease in diabetes mellitus
Debabrata Mukherjee
SECTION 13:DIABETES AND PUBLIC HEALTH
76 Thediabetes challenge: from human and social rights to the empowerment of peoplewith diabetes
C.T. Di Iorio, Fabrizio Carinci & M. Massi Benedetti
77 Theeconomics of diabetes care: a global perspective
Rhys Williams
Index
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