Description The undisputed gold standard text in the field,Ryan's Retina is your award-winning choice for the most current, authoritativeinformation on new technologies, surgical approaches, scientific advances anddiagnostic and therapeutic options for retinal diseases and disorders. Packedwith timely updates throughout, new illustrations, and a dedicated team ofeditors who extend Dr. Ryan's legacy in retina, this outstanding 6th Edition isa must-have reference for retinal specialists, ophthalmologists, and fellows intraining. New to this Edition Bullets Includes new chapters on widefieldimaging, intraoperative OCT imaging, medical management of diabetes mellitusand age-related macular degeneration, and senile retinoschisis. Includes morethan 1,150 brand-new illustrations, scans, and photographs throughout. Coversthe explosion of new imaging options across optical coherence tomography (OCT),fundus imaging, and autofluorescence imaging, including a greatly expanded OCTimaging chapter that features crucial information on OCT-Angiography (OCT-A). Presentsnew pharmacotherapy data and the latest approaches in anti-VEGF therapy forage-related macular degeneration, diabetic retinopathy, and venous occlusivedisease. Features an expanded online video library highlighting the latestsurgical techniques and new coverage of complications of vitreoretinal surgery.Contains thorough content updates in every area of retina, including advancedimaging technologies, gene therapy, inflammation and immune responses, whitedot syndromes, epigenetic mechanisms, transplantation frontiers to improveretinal function, macular hole, myopic eye disease, ocular trauma, drugdelivery to the posterior segment, advances in macular surgery, vitrectomy andcomplex retinal detachment, tumors, and retinal genetics and biology. ExpertConsult� eBook version includedwith purchase. This enhanced eBook experience allows you to search all of thetext, figures, Q&As, and references from the book on a variety of devices. KeyFeatures Offers the most comprehensive content available on retina, balancingthe latest scientific research and clinical correlations, covering everythingyou need to know on retinal diagnosis, treatment, development, structure,function, and pathophysiology. Provides a truly global perspective from fivehighly esteemed section editors and more than 350 other world authorities fromacross Europe, Asia, Australasia, and the Americas. Author Information ByAndrew P. Schachat, MD, Vice Chairman, Cole Eye Institute, Cleveland ClinicFoundation, Cleveland, OH, USA ; Charles P. Wilkinson, MD MD, Chairman,Department of Ophthalmology, Greater Baltimore Medical Center; Professor,Department of Ophthalmology, John Hopkins University, Baltimore, MD, USAChairman, Department of Ophthalmology, Greater Baltimore Medical Center andProfessor, Department of Ophthalmology, Johns Hopkins University, Baltimore,MD, USA; David R. Hinton, MD, Gavin S. Herbert Professor of Retinal Research;Professor of Pathology and Ophthalmology, Department of Ophthalmology, KeckSchool of Medicine, University of Southern California, Los Angeles, CA, USA ;SriniVas R. Sadda, MD, Associate Professor of Ophthalmology, Doheny EyeInstitue, Los Angeles, CA, USA and Peter Wiedemann, MD, Professor and Chair,Department of Ophthalmology, University of Leipzig, Leipzig, Germany ContentsPart I: Retinal Imaging and Diagnostics 1. Fluorescein Angiography: BasicPrinciples and Interpretation 2. Clinical Applications of DiagnosticIndocyanine Green Angiography 3. Optical Coherence Tomography 4.Autofluorescence Imaging 5. Widefield Imaging 6. Intraoperative OCT Imaging 7. AdvancedImaging Technologies 8. Advanced Image Analysis 9. Electrogenesis of the Electroretinogram10. Clinical Electrophysiology 11. Diagnostic Ophthalmic Ultrasound 12. ColorVision and Night Vision 13. Visual Acuity and Contrast Sensitivity 14. VisualFields in Retinal Disease Part 2: Basic Science and Translation to TherapySection 1: Anatomy and Physiology 15. The Development of the Retina 16.Structure and Function of Rod and Cone Photoreceptors 17. Function and Anatomyof the Mammalian Retina 18. Cell Biology of the Retinal Pigment Epithelium 19. CellBiology of Retinal Glia 20. Retinal and Choroidal Vasculature: RetinalOxygenation 21. Mechanisms of Normal Retinal Adhesion 22. Structure, Function,and Pathology of Bruch's Membrane 23. Vitreous and Vitreoretinal InterfaceSection 2: Basic Mechanisms of Injury in the Retina 24. Mechanisms of OxidativeStress in Retinal Injury 25. Mechanisms of Endoplasmic Reticulum Stress inRetinal Disease 26. Cell Death, Apoptosis, and Autophagy in Retinal Injury 27.Inflammation and Immune Responses In Retinal Health and Disease 28. BasicMechanisms of Pathological Retinal and Choroidal Angiogenesis 29. Blood-RetinalBarrier, Immune Privilege, and Autoimmunity 30. Mechanisms of Macular Edema andTherapeutic Approaches 31. Cellular Effects of Detachment and Reattachment onthe Neural Retina and the Retinal Pigment Epithelium 32. Pathogenesis of SerousDetachment of the Retina and Pigment Epithelium Section 3: Genetics 33. GeneticMechanisms of Retinal Disease 34. Mitochondrial Genetics of Retinal Disease 35.Epigenetic Mechanisms of Retinal Disease Section 4: Translational Basic Science36. Gene Therapy for Retinal Disease 37. Stem Cells and Cellular Therapy 38.Nanomedicine in Ophthalmology 39. Neuroprotection 40. Drug Delivery 41. RetinalLaser Therapy: Biophysical Basis and Applications Medical Retina Section 1:Retinal Degenerations and Dystrophies 42. Retinitis Pigmentosa and AlliedDisorders 43. Hereditary Vitreoretinal Degenerations 44. Macular Dystrophies45. Hereditary Choroidal Diseases 46. Abnormalities of Cone and Rod FunctionSection 2: Retinal Vascular Disease 47. The Epidemiology of DiabeticRetinopathy 48. Diabetic Retinopathy: Genetics and Etiologic Mechanisms 49. MedicalManagement of Diabetes Mellitus 50. Nonproliferative Diabetic Retinopathy andDiabetic Macular Edema 51. Proliferative Diabetic Retinopathy 52. Hypertension53. Telescreening for Diabetic Retinopathy 54. Retinal Artery Occlusions 55. AcquiredRetinal Macroaneurysms 56. Branch Vein Occlusion 57. Central Retinal VeinOcclusion 58. Macular Telangiectasia 59. Coats Disease 60. Hemoglobinopathies61. Radiation Retinopathy 62. Ocular Ischemic Syndrome 63. Coagulopathies 64.Pediatric Retinal Vascular Diseases Retinopathy of Prematurity 65.Telescreening for Retinopathy of Prematurity Section 3: ChoroidalVascular/Bruch's Membrane Disease 66. Epidemiology and Risk Factors forAge-Related Macular Degeneration 67. Pathogenetic Mechanisms in Age-RelatedMacular Degeneration 68. Age-Related Macular Degeneration: Non-neovascularEarly AMD, Intermediate AMD, and Geographic Atrophy 69. Neovascular (Exudativeor "Wet") Age-Related Macular Degeneration 70. Pharmacotherapy ofAge-Related Macular Degeneration 71. Pathologic Myopia 72. Angioid Streaks 73.Ocular Histoplasmosis 74. Polypoidal Choroidal Vasculopathy 75. Central SerousChorioretinopathy 76. Uveal Effusion Syndrome and Hypotony Maculopathy Section4: Inflammatory Disease/Uveitis 77. Sympathetic Ophthalmia 78.Vogt-Koyanagi-Harada Disease 79. White Spot Syndromes and Related Diseases 80. AutoimmuneRetinopathies 81. Sarcoidosis 82. Intermediate Uveitis 83. Rheumatic Diseases84. HIV-Associated Infections 85. Mycobacterial Infections 86. Eales Disease87. Spirochetal Infections 88. Ocular Toxoplasmosis 89. Helminthic Disease 90. EndogenousEndophthalmitis: Bacterial and Fungal 91. Acute Retinal Necrosis SyndromeSection 5: Miscellaneous 92. Drug Toxicity of the Posterior Segment 93. PhoticRetinal Injuries: Mechanisms, Hazards, and Prevention 94. TraumaticChorioretinopathies 95. Pregnancy-Related Diseases 96. Optic Disc Anomalies,Pits, and Associated Serous Macular Detachment 97. Retina-Related ClinicalTrials: A Resource Bibliography Surgical Retina Section 1: The Pathophysiologyof Retinal Detachment and Associated Problems 98. Pathogenetic Mechanisms ofRetinal Detachment 99. Nonrhegmatogenous Retinal Detachment 100. SenileRetinoschisis 101. Pathogenesis of Proliferative Vitreoretinopathy 102.Pathophysiology of Ocular Trauma Section 2: Retinal Reattachment: GeneralSurgical Principles and Techniques 103. The Effects and Action of ScleralBuckles in the Treatment of Retinal Detachment 104. Techniques of ScleralBuckling 105. Principles and Techniques of Vitreoretinal Surgery 106. PrimaryVitrectomy in Rhegmatogenous Retinal Detachment 107. Pneumatic Retinopexy 108.Special Adjuncts to Treatment 109. Optimal Procedures for Retinal DetachmentRepair 110. Prevention of Retinal Detachment Section 3: Complicated Forms ofRetinal Detachment 111. Proliferative Vitreoretinopathy 112. Retinotomies andRetinectomies 113. Giant Retinal Tear 114. Surgery for Ocular Trauma:Principles and Techniques of Treatment 115. Surgery for Proliferative DiabeticRetinopathy 116. Management of Combined Inflammatory and Rhegmatogenous RetinalDetachment 117. High Myopia and the Vitreoretinal Complications 118. SurgicalManagement of Retinopathy of Prematurity 119. Surgery for PediatricVitreoretinal Disorders Section 4: Vitreous Surgery for Macular Disorders 120. EpiretinalMembranes, Vitreoretinal Traction and Cystoid Macular Edema 121. Macular Hole122. Surgical Management of Choroidal Neovascularization and SubretinalHemorrhage 123. 360 Degree Macular Translocation 124. Retinal PigmentEpithelium and Choroid Translocation in Patients with Age-Related MacularDegeneration Section 5: Vitreous Surgery: Additional Considerations 125. InfectiousEndophthalmitis 126. Diagnostic and Therapeutic Vitrectomy for Uveitis 127 .Vitreous, Retinal, and Choroidal Biopsy 128. Transplantation Frontiers 129 .Artificial Vision 130. Pharmacology During Surgery 131. Complications InVitreoretinal Surgery Tumors of the Retina, Choroid, and Vitreous Section 1:Tumors of the Retina 132. Retinoblastoma 133. Cavernous Hemangioma 134.Capillary Hemangioblastoma of the Retina and von Hippel-Lindau Disease 135. TuberousSclerosis and the Eye 136. Phakomatoses 137. Retinal Metastases 138. RemoteEffects of Cancer on the Retina 139. Melanocytoma of the Optic Disc 140.Congenital Hypertrophy of the Retinal Pigment Epithelium 141. CombinedHamartoma of the Retinal Pigment Epithelium and Retina Section 2: Tumors of theChoroid 142. Choroidal Nevi 143. Epidemiology of Posterior Uveal Melanoma 144.Prognosis of Posterior Uveal Melanoma 145. Molecular Genetics of ChoroidalMelanoma 146. Pathology of Choroidal Melanoma 147. Overview of Management ofPosterior Uveal Melanoma 148. Enucleation for Choroidal Melanomas 149.Brachytherapy for Choroidal Melanoma 150. Charged-Particle Irradiation of UvealMelanoma 151. Surgical Resection of Choroidal Melanoma 152. Laser Treatment ofChoroidal Melanoma 153. Systemic Evaluation and Management of Patients withMetastatic Uveal Melanoma 154. Collaborative Ocular Melanoma Study 155.Choroidal Metastases 156. Choroidal Osteoma 157. Circumscribed ChoroidalHemangioma Section 3: Hematologic and Miscellaneous Tumors 158. MiscellaneousUveal Tumors 159. Leukemias and Lymphomas 160. Primary Vitreoretinal Lymphoma
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