MOSAIC OF AUTOIMMUNITY. THE NOVEL FACTORS OF AUTOIMMUNE DISEASES

DESCRIPTION

The Mosaicof Autoimmunity: The Novel Factors of Autoimmune Diseasesdescribesthe multifactorial origin and diversity ofexpression of autoimmune diseases in humans. The termimplies that different combinations of factors in autoimmunityproduce varying and unique clinical pictures in a wide spectrum of autoimmunediseases. Most of the factorsinvolved in autoimmunitycan be categorized into four groups: genetic,immune defects, hormonal and environmental factors. In this book, the environmentalfactors are reviewed, including infectious agents, vaccines as triggers of autoimmunity,smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases.

An entirelynew syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included,along with other diseases that are now recognizedas having an autoimmune etiopathogenesis.

Key Features:

-        Highlights the concept ofthe mosaic of autoimmune manifestations

-        Includes new visions onunsuspected molecules

-        Provides updated knowledge to physicians helpingpatients with autoimmune diseases

-        Presents thorough, up-to-date information on specific diseases, along with clinicalapplications

TABLE OF CONTENTS

Introduction
1. The history of the mosaicof autoimmunity
2. The novel aspects on the mosaicof autoimmunity

Cellular andmolecular mechanisms
3. B cells
4. B-reg 
5. T cells
6. Th17 cells
7. NK cells
8. Dendritic cells
9. Complement
10. Autoantibodies
11. Anti-DSF70
12. Genetic
13. Epigenetic
14. Post-translational modifications
15. Cytokines and chemokines
16. Autophagy
17. Diagnostic: laboratory 
18. Diagnostic: imaging

The classicalfactors associated with autoimmunity
19. Hormones
20. Microbiota
21. Infections: Viruses and bacteria

The novel environmentalfactors associated with autoimmunity
22. Geo-epidemiology
23. Seasonality
24. UV
25. Vitamin D
26. Vitamin D pregnancy and autoimmunity
27. Smell
28. Breast feeding
29. Vaccines
30. Silicone
31. Diet: spicy food and fatty acids
32. Diet: gluten
33. Psychological stress
34. Coffee
35. Obesity
36. Physical activity
37. Smoke
38. Cannabis
39. Bisphenol
40. Prolactin

Peculiar aspects
41. Cancer
42. Paraneoplastic syndromes

Classical autoimmunediseases
43. SLE
44. APS
45. CAPS
46. RA and inflammatory arthritides
47. PsA and Spondyloarthropathies
48. MS, MG and other neurological disorders
49. Systemic slcerosis
50. Sjogren
51. ASIA syndrome
52. Reproductive failure
53. Accelerated atherosclerosis
54. New autoimmune diseases

Treatment ofautoimmune diseases
55. Neuroimmunology
56. Vasculitis
57. Personalized Medicine
58. Biologics and Biosimilars
59. Small molecules
60. Helminthes
61. Novel therapies and IVIg
62. Autoimmune and allergic disease
63. EBV Molecular Diagnosis
64. Statin and myositis
65. Autoimmunity and primary immunodeficiency