CARDIOVASCULAR PATHOLOGY (ONLINE AND PRINT)

DESCRIPTION

Cardiovascular Pathology, Fourth Edition, provides users with a comprehensiveoverview that encompasses its examination, cardiac structure, both normal and physiologically altered, and a multitude of abnormalities.This updated edition offerscurrent views on interventions, both medical and surgical, and the pathologyrelated to them.
Congenital heart disease and itspathobiology are covered insome depth, as are vasculitis and neoplasias. Each section has been revised toreflect new discoveries in clinical and molecular pathology, with new chaptersupdated and written with a practical approach, especially with regards to thediscussion of pathophysiology. New chapters reflect recent technological advances with cardiacdevices, transplants, genetics, and immunology.Each chapter is highly illustratedand covers contemporary aspects of thedisease processes, including a section on the role ofmolecular diagnostics and cytogenetics as specifically related to cardiovascular pathology.

Key Features

-        Serves as a contemporary, all-inclusive guide to cardiovascular pathology for cliniciansand researchers, as well as clinical residents and fellowsof pathology, cardiology, cardiac surgery, and internalmedicine

-        Offers new organization of each chapterto enable uniformity for learning and reference:Definition, Epidemiology,Clinical Presentation, Pathogenesis/Genetics, Light and Electron Microscopy/Immunohistochemistry, DifferentialDiagnosis, Treatment and Potential Complications

-        Features six new chaptersand expanded coverage of thenormal heart and blood vessels, cardiovascular devices, congenital heart disease, tropical and infectious cardiac disease, and forensic pathologyof the cardiovascular system

-        Contains 400+ fullcolor illustrations and an online image collection facilitate research, study, and lecture slide creation

TABLE OF CONTENTS

Dedication
Preface
Acknowledgments
Chapter 1: Anatomic Considerations and Examination of Cardiovascular Specimens (Excluding Devices)
Abstract
Gross Examination of the Heart
Examination of Surgical Cardiovascular Specimens
Microscopic Examination of the BloodVessels and Heart
Chapter 2: Age-related Cardiovascular Changes and Diseases
Abstract
Nonspecific Cardiovascular Changesof Aging
Changes in the Conduction System
Changes in Arteries
Age-related Diseases
Disorders of Premature Aging
Telomere
Chapter 3: Vascular Pathobiology:Atherosclerosis and Large Vessel Disease
Abstract
Introduction to Atherosclerosis
Epidemiology and Risk Factors
Gross and Microscopic Morphology of theFibroinflammatory LipidPlaque
Steps in AtheroscleroticPlaque Formation and Complications
Cellular Function and Pathways in Atherogenesis
Nonatherosclerotic Diseasesof the Aorta
Chapter 4: Diseases of Small andMedium-sized Blood Vessels
Abstract
Introduction
Vascular Activation and Common Vascular Pathologic Changes
Congenital Vascular Diseases
Genetic Vascular Disorders
Endocrine/MetabolicVascular Disorders
Vasculitis
Infection
Toxic Vasculopathies
Coagulopathic Disorders
Hypertension
Vascular Deposition Disorders
Intimal Proliferative Diseases
Arterial Dissections
Miscellaneous Conditions
Disorders of Veins
Chapter 5: Aneurysms of the Aorta: Ascending,Thoracic and Abdominal and Their Management
Abstract
Introduction
Normal Anatomy and Histology of theAorta
Aging Changes of the Aorta
Thoracic Aortic Aneurysms
Etiology and Pathologic Findings
Clinical Presentation andNatural History
Abdominal Aortic Aneurysm
Aortic Dissection
Management
Chapter 6: Fundamental Principlesin Cardiovascular Genetics
Abstract
Genetic Variation
Modern Molecular Diagnostics
Identifying the Genetic Basis of Cardiovascular Disease
Representative GeneticCardiovascular Conditions
Molecular Diagnostics in Cardiovascular Pathology Practice
Chapter 7: Myocardial Ischemia and ItsComplications
Abstract
Definition and History
Clinical Manifestations
Epidemiology
Biochemical Changes with Ischemia andBiochemical Markers
Ultrastructural Evolution of Acute IschemicInjury
Cellular and Subcellular Mechanisms of Myocardial Injury
Microscopic Evolution of Acute IschemicInjury
Morphology of Coronary Arteries and Plaques
Tako-Tsubo Cardiomyopathy
Gross Evolution of Acute Ischemic Injury
Patterns of MI
Phenomena Associated with Ischemic Injury
Reperfusion of Ischemic Myocardium
Complications of MI
Recognition and Quantification of Acute Ischemic Injury
Pathology of Interventions
Pathophysiological and Pharmacological Interventions
Molecular Biology of Myocardial Ischemia
Chapter 8: Pathophysiology of Heart Failureand an Overviewof Therapies
Abstract
Overview of Heart Failure
Pathophysiology of HF
Neurohormonal Alterationsin HF
Signaling Responses to Various Stimuli During HF
HF-related Alterations in Cellular Function and Biochemical Pathways
Metabolic Remodeling in HF
Summary of HF
Therapeutic Management of HF
Chapter 9: Myocarditis
Abstract
Definition of Myocarditis
Diagnosis of Myocarditis
Histopathologic Patterns of Myocarditis
Etiologies of Myocarditis
Treatment of Myocarditis
Chapter 10: Pathology of Sudden Death,Cardiac Arrhythmias and Conduction System
Abstract
Acknowledgments
Sudden Death
Cardiac Conduction System
Atrial Fibrillation
Appendix Guidelines for Postmortem Study of Sudden Death
Chapter 11: Cardiomyopathies
Abstract
Definition and Classification of Cardiomyopathies
Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy
Arrhythmogenic Cardiomyopathy
Restrictive Cardiomyopathy
Others
Chapter 12: Valvular Heart Disease
Abstract
Introduction
Functional Anatomy
Types of Valvular Dysfunction
Chapter 13: Cardiac Valve Replacement and Related Interventions
Abstract
General Considerations
Valve-related Complications: Clinical Importance,Morphology, Secondary Effects, and Pathogenesis
Other Tissue Valve Substitutes
Catheter-based Valve Implantation
Valve Repair and Valve SparingProcedures
New Developments and Future Considerations
Pathologic Considerationsin Analysis of Heart Valve Substitutes
Disclosure
Appendix
Chapter 14: The Pathology of Cardiovascular Interventions and Devices for CoronaryArtery Disease, Vascular Disease, Heart Failure, and Arrhythmias
Abstract
Endovascular Therapies and Myocardial Revascularization
Aortic and Peripheral Vascular Replacement and Reconstruction
Cardiac Assist and Replacement
Arrhythmia Control
Chapter 15: Congenital Heart Disease: Pathology, Natural History, and Interventions
Abstract
Introduction
Epidemiology and Etiology
Embryology of the Cardiovascular System
Clinical Features and Consequences
Specific Forms of CHD
Surgical and Nonsurgical Interventions for Treatment ofCHD
CHD in the Adult
Natural History of CHD Without andwith Interventions
Chapter 16: The Pericardium and Its Diseases
Abstract
Anatomy
Physiology
Histology
Echocardiography
Pericardiocentesis and Biopsy
Congenital Abnormalities
Pericardial Effusion After Cardiac Surgery
Pneumopericardium
Early Postmyocardial Infarction Pericarditis and Dressler Syndrome
Iatrogenic and Traumatic Pericarditis
Chapter 17: Pathology of Cardiac Transplantation
Abstract
General Clinicopathologic Considerations
Pathology of the Explanted RecipientHeart
Pathology of the Donor Heart
Pathology of the Allograft
Heart Transplantation in Combination with Other Organs
Pathological Review of an EMB
Approach to the Examination of a Failed Allograft
Future Considerations
Chapter 18: Toxins and the Heart
Abstract
Introduction
Endocardium
Myocardium
Pericarditis
Primary Conduction System Abnormalities
Coronary Artery Lesions
Cocaine-Other Drug Interactions
Drugs to Treat Attention Deficit-Hyperactivity Disorders
Antipsychotic Medications
Nonsteroidal Anti-inflammatory Drugs
Myocardial Toxins as aCause of Death
Chapter 19: Tumors of the Cardiovascular System: Heart andBlood Vessels
Abstract
Incidence and Classification
Clinical Symptoms
Reactive Cardiac Masses and Pseudotumors
Ectopias
Hamartomas and Benign Neoplasms
Hamartomas of Cardiac Muscle
Benign Fatty Tumors
Benign Tumors of Myofibroblastic Tissue
Miscellaneous Benign Fibrous Tumors
Cardiac Myxoma
Benign Neural Neoplasms
Malignant Tumors
Metastatic Tumors
Sarcomas of the Great Vessels
Chapter 20: Forensic Aspects of Cardiovascular Pathology
Abstract
Investigative Information
General Changes
Primary Diseases/Injuries of the Heart
Cardiomyopathies, Myocarditis,and Genetic Causes of SCD
Anomalies and Diseases of theAorta and Coronary Arteries
Diseases of the Cardiac Valves
Ancillary Studies
Sudden Death Following Surgery and Medical Procedures
Organ and Tissue Harvesting
Cardiovascular Pathology Consultation

Summary
Index