DIAGNOSTIC PATHOLOGY. ENDOCRINOLOGY

DESCRIPTIÓN

This expertvolume in the Diagnostic Pathology series is an excellent point-of-careresource for practitioners at all levels of experience and training. Coveringall areas of endocrine pathology, it incorporates the most recent clinical,pathologic, and molecular knowledge in this challenging field to provide acomprehensive overview of all key issues relevant to today's practice. Richlyillustrated and easy to use, the third edition of Diagnostic Pathology:Endocrine is a one-stop reference for accurate, complete pathology reports,ideal as a day-to-day reference or as a reliable training resource.

Providesessential knowledge in all areas of endocrine pathology, including thyroid,parathyroid, pituitary, adrenal, paraganglia, pancreas, skin, neuroendocrineneoplasms, and inherited tumor syndromes-more than 150 diagnoses in all
Offers a wealth of new information based on recently recognized and discoveredendocrine diseases, as well as tumor types with important implications forpatient care
Includes new content on thyroid lesions and tumors now associated with DICER1gene mutations; the correlation of newly characterized genetic abnormalities inendocrine tumors associated with responses to targeted therapies; and newlyrecognized syndromes, such as multiple endocrine neoplasia type 4 and type 5,glucagon cell hyperplasia and neoplasia, and others
Meticulously edited by Dr. Vania Nose with contributions from renownedpathologists to ensure that common/classic endocrine diagnoses as well as newlyrecognized diseases and unusual cases, are well covered
Features nearly 2,200 high-quality images in print and online, includingclinical and histologic images, gross pathology images, radiologic images, and full-colorillustrations to help practicing and in-training pathologists reach a confidentdiagnosis
Includes updated criteria, terminology, and classifications for a wide range oftumors according to the latest literature, including the 2022 WHO Endocrine andNeuroendocrine Tumors classification
Employs consistently templated chapters, bulleted content, key facts, andannotated images for quick, expert reference at the point of care
Includes the enhanced eBook version, which allows you to search all text, figures,and references on a variety of devices

INDEX

SECTION 1:

THYROIDNONNEOPLASTIC HEREDITARY/GENETIC/CONGENITAL

4 Thyroglossal DuctCyst Vania Nose, MD, PhDand Nicole A. Cipriani, MD 8 Ectopic Thyroid Vania Nose, MD, PhD 12Solid Cell Nests Vania Nose,MD, PhD 16 Dyshormonogenetic GoiterVania Nose, MD, PhD

INFECTIOUS

22 Acute Thyroiditis Vania Nose, MD, PhD

AUTOIMMUNE/INFLAMMATORY

26 Subacute/GranulomatousThyroiditis Vania Nose, MD,PhD 32 Palpation ThyroiditisVania Nose, MD, PhD and Nicole A. Cipriani, MD 34IgG4-Related Thyroid DiseaseVania Nose, MD, PhD 38 RiedelThyroiditis Vania Nose, MD,PhD 44 Hashimoto Thyroiditis Vania Nose, MD, PhD 52 Graves Disease (Diffuse Hyperplasia) Suzana Leite, MD and Vania Nose, MD, PhD 60 Amyloid Goiter Vania Nose, MD, PhD

REACTIVE

66 Pigments and Crystals, Thyroid Nicole A.Cipriani, MD and Vania Nose, MD, PhD 72 Post-FNA SiteChanges, Thyroid Vania Nose, MD, PhD and Darcy A. Kerr, MD

NEOPLASTIC FOLLICULAR CELL-DERIVED NEOPLASMS

74 Thyroid FollicularNodular Disease Vania Nose,MD, PhD 80 Adenomatous NodulesVania Nose, MD, PhD and Lori A. Erickson, MD 86 Follicular Thyroid Adenoma Vania Nose, MD, PhD and Lori A. Erickson, MD 94 Follicular Thyroid Adenoma With Papillary Architecture Vania Nose, MD, PhD98 Oncocytic ThyroidAdenoma Vania Nose, MD, PhD and Lori A. Erickson, MD102 Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features Vania Nose, MD, PhD andYing-Hsia Chu, MD 112 HyalinizingTrabecular Tumor of Thyroid Vania Nose,MD, PhD and Nicole A. Cipriani, MD 118 Follicular Thyroid Carcinoma Vania Nose, MD,PhD and Lori A. Erickson, MD 128 Oncocytic Thyroid Carcinoma Ying-Hsia Chu,MD and Vania Nose, MD, PhD 132 Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinoma Vania Nose, MD,PhD and Lori A. Erickson, MD 140 Kinase Fusion-Related Thyroid CarcinomasYing-Hsia Chu, MD and Vania Nose,MD, PhD 148 Follicular Cell-DerivedThyroid Carcinoma, High Grade Nicole A. Cipriani, MDand Vania Nose, MD, PhD 158 AnaplasticThyroid Carcinoma Vania Nose,MD, PhD and Lori A. Erickson, MD 168 Papillary Thyroid Carcinoma Vania Nose, MD,PhD and Ying-Hsia Chu, MD 182 ClassicPapillary Thyroid CarcinomaVania Nose, MD, PhD and Julie Guilmette,MD, FRCPC 190 Infiltrative Follicular Variant Papillary Thyroid Carcinoma Vania Nose, MD,PhD and Lori A. Erickson, MD 194 Macrofollicular Papillary Thyroid Carcinoma VaniaNose, MD, PhD 200 Diffuse Sclerosing Papillary Thyroid Carcinoma Nicole A. Cipriani, MD and Vania Nose, MD, PhD 206 Oncocytic Papillary Thyroid Carcinoma VaniaNose, MD, PhD and Peter M. Sadow,MD, PhD 210 Tall Cell PapillaryThyroid Carcinoma Vania Nose,MD, PhD and Julie Guilmette, MD, FRCPC 218 ColumnarCell Papillary ThyroidCarcinoma Vania Nose, MD, PhD and Lori A. Erickson,MD 222 Clear Cell Papillary ThyroidCarcinoma Vania Nose, MD, PhD and Julie Guilmette, MD, FRCPC 224 Solid/Trabecular Papillary Thyroid Carcinoma VaniaNose, MD, PhD and Julie Guilmette,MD, FRCPC 228 Hobnail PapillaryThyroid Carcinoma Julie Guilmette,MD, FRCPC and Vania Nose, MD, PhD 234 Warthin-Like Papillary Thyroid Carcinoma Vania Nose, MD,PhD

C-CELL-DERIVED TUMORS

240 C-Cell Hyperplasia Vania Nose, MD, PhD and Adam S. Fisch,MD, PhD 246 Medullary ThyroidCarcinoma Vania Nose, MD, PhD and Adam S. Fisch, MD, PhD

MIXED MEDULLARY AND FOLLICULAR CELL CARCINOMA

256 Mixed Medullaryand Follicular Cell-DerivedThyroid Carcinoma Vania Nose,MD, PhD and Darcy A. Kerr, MD

THYMIC TUMORS WITHIN THYROID

260 Spindle EpithelialTumor With Thymus-Like Differentiation Vania Nose, MD,PhD 266 Intrathyroid ThymicCarcinoma Vania Nose, MD, PhD

SALIVARY GLAND-LIKE THYROID TUMORS

274 Mucoepidermoid Carcinoma of Thyroid Darcy A. Kerr, MD and Vania Nose,MD, PhD 278 Secretory Carcinoma of Salivary Gland Type Darcy A. Kerr, MD and Vania Nose,MD, PhD

HEMATOLYMPHOID TUMORS

282 Lymphoma, ThyroidJudith Ferry, MD 288 Follicular DendriticCell Sarcoma, Thyroid Vania Nose,MD, PhD and Darcy A. Kerr, MD 292 Langerhans Cell Histiocytosis,Thyroid Vania Nose, MD, PhDand Dipti P. Sajed, MD, PhD

GERM CELL ORIGIN

296 Benign ThyroidTeratoma Vania Nose, MD, PhD 302 StrumaOvarii, Struma Carcinoid, and Malignant Struma Ovarii Vania Nose, MD, PhD

EMBRYONAL THYROID TUMORS

310 Thyroblastoma Vania Nose, MD, PhD and Julie Guilmette,MD, FRCPC

MESENCHYMAL AND STROMAL TUMORS

316 Peripheral NerveSheath Tumor, Thyroid VaniaNose, MD, PhD and Darcy A. Kerr, MD 320 Solitary Fibrous Tumor, Thyroid Dipti P. Sajed, MD, PhD and Vania Nose,MD, PhD 326 Paraganglioma, ThyroidLori A. Erickson, MD and Vania Nose, MD, PhD 332 Leiomyoma and Leiomyosarcoma, Thyroid Dipti P. Sajed, MD, PhD and Vania Nose,MD, PhD 336 Angiosarcoma, ThyroidDipti P. Sajed, MD, PhD andVania Nose, MD, PhD 340 PrimaryEwing Sarcoma, Thyroid DiptiP. Sajed, MD, PhD and Vania Nose,MD, PhD

SECONDARY TUMORS WITHIN THYROID

344 Metastasis toThyroid Gland Vania Nose, MD, PhD and Darcy A. Kerr, MD

TUMORS OF UNCERTAIN HISTOGENESIS

350 Cribriform MorularThyroid Carcinoma Vania Nose,MD, PhD 360 Sclerosing MucoepidermoidCarcinoma With EosinophiliaDarcy A. Kerr, MD and Vania Nose, MD, PhD

MOLECULAR PATHOLOGY OF THYROID NEOPLASMS

366 Molecular Pathologyof Thyroid Neoplasms Vania Nose, MD, PhD and Ying-Hsia Chu,MD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITHCARCINOMA OF THYROID GLAND

372 Thyroid Carcinoma Protocol Vania Nose, MD, PhD andJulie Guilmette, MD, FRCPC

SECTION 2:

PARATHYROID GLAND NONNEOPLASTIC

376 Primary MultiglandularParathyroid Disease Lori A.Erickson, MD 386 Primary ParathyroidClear Cell Hyperplasia Lori A. Erickson, MD 390 Secondary Parathyroid Hyperplasia Lori A. Erickson, MD 396 TertiaryParathyroid HyperplasiaLori A. Erickson, MD 400 Chronic ParathyroiditisLori A. Erickson, MD

NEOPLASTIC

404 Parathyroid Adenoma Lori A.Erickson, MD and Vania Nose, MD, PhD 412 Parathyroid Lipoadenoma Lori A.Erickson, MD 416 Atypical ParathyroidTumor Vania Nose, MD, PhD and Lori A. Erickson, MD422 Parathyroid Carcinoma Vania Nose,MD, PhD and Lori A. Erickson, MD 432 Metastasis to Parathyroid Gland Lori A. Erickson, MD

SECTION 3:

ADRENAL GLANDS ADRENAL CORTICAL NONNEOPLASTIC

438 Adrenal Heterotopia Arthur S. Tischler, MD 440 Adrenal Hypoplasiaand Malformations Nada A. Farhat,MD, MA, MPH and Arthur S. Tischler, MD 444 Adrenal Cytomegaly Nada A. Farhat, MD,MA, MPH and Arthur S. Tischler, MD 446 Infectious Disorders, Adrenal Glands Arthur S. Tischler, MD andNada A. Farhat, MD, MA, MPH 450 AutoimmuneAdrenalitis Arthur S. Tischler,MD and Nada A. Farhat, MD, MA, MPH 452 Adrenal Amyloidosis Arthur S. Tischler,MD and Nada A. Farhat, MD, MA, MPH 456 IncidentalAdrenal Nodules Nada A. Farhat,MD, MA, MPH and Arthur S. Tischler, MD 460 Adrenal Cysts Nada A. Farhat, MD, MA, MPHand Arthur S. Tischler, MD

ADRENAL CORTICAL NEOPLASTIC

466 Adrenocortical Hyperplasia andAdrenocortical Nodular Disease Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler,MD 472 Primary PigmentedNodular Adrenocortical Disease Vania Nose, MD, PhD 478 NonfunctioningAdrenal Cortical Adenoma Vania Nose, MD, PhD andPeter M. Sadow, MD, PhD 480 Aldosterone-ProducingAdenoma Vania Nose, MD, PhD and Patricia Nogueira deSa, MD 486 Cortisol-Secreting Adrenal CorticalAdenoma Vania Nose, MD, PhD and Peter M. Sadow, MD, PhD 492 Sex Hormone-ProducingAdrenal Cortical Adenoma Vania Nose, MD, PhD andPeter M. Sadow, MD, PhD 494 OncocyticAdrenal Cortical Adenoma Vania Nose, MD, PhD andPeter M. Sadow, MD, PhD 498 Adrenal CorticalCarcinoma Vania Nose, MD, PhD and Ying-Hsia Chu, MD 510 Adrenal Cortical Neoplasmsin Children Vania Nose, MD,PhD

ADRENAL MEDULLA AND PARAGANGLIA

518 Adrenal MedullaryHyperplasia Vania Nose, MD,PhD 522 Pheochromocytoma and ParagangliomaVania Nose, MD, PhD, Arthur S. Tischler,MD, and Ying-Hsia Chu, MD 534 Composite Pheochromocytoma and Composite ParagangliomaVania Nose, MD, PhD and Arthur S. Tischler,MD 540 Neuroblastic Tumorsof Adrenal Gland Vania Nose,MD, PhD

ADRENAL MESENCHYMAL AND STROMAL TUMORS

552 Primary Adrenal Myelolipoma Vania Nose, MD, PhD556 Primary Adrenal Melanoma Vania Nose, MD, PhD 560 Primary AdrenalBenign Connective Tissue Tumor Vania Nose, MD, PhD562 Primary Adrenal AngiosarcomaVania Nose, MD, PhD 566 PrimaryAdrenal Leiomyosarcoma Vania Nose,MD, PhD 570 Metastasis toAdrenal Gland Vania Nose,MD, PhD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITHCARCINOMA OF ADRENAL GLAND

574 Adrenal Cortical Carcinoma Protocol Vania Nose, MD, PhD

SECTION 4:

PITUITARY GLAND NONNEOPLASTIC

578 Hypophysitis, Pituitary Gland M.Beatriz S. Lopes,MD, PhD 582 Hyperplasia, PituitaryGland M.Beatriz S. Lopes, MD, PhD 584 Sarcoidosis, PituitaryGland M.Beatriz S. Lopes, MD, PhD and Vania Nose,MD, PhD 588 Infarction, PituitaryGland M.Beatriz S. Lopes, MD, PhD 590 Sheehan Syndrome,Pituitary Gland M.Beatriz S. Lopes, MD, PhD 592 Cystic Lesions of Sellar Region M.Beatriz S. Lopes, MD, PhD 596 Empty Sella Syndrome M.Beatriz S. Lopes, MD, PhD

NEOPLASTIC ANTERIOR NEUROENDOCRINE NEOPLASMS

598 Pituitary NeuroendocrineTumor/Adenoma M.Beatriz S. Lopes,MD, PhD and Vania Nose, MD, PhD 604 Somatotroph PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 608 Lactotroph PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 612 Thyrotroph PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 616 Plurihormonal PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 620 Corticotroph PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 624 Gonadotroph PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 628 Null Cell PitNET/Adenoma M.Beatriz S. Lopes, MD, PhD 630 Metastatic PituitaryNeuroendocrine Tumor Vania Nose, MD, PhD and M.Beatriz S. Lopes, MD, PhD

OTHER ANTERIOR PITUITARY TUMORS

634 Adamantinomatous Craniopharyngioma M.BeatrizS. Lopes, MD, PhD 636 PapillaryCraniopharyngioma M.BeatrizS. Lopes, MD, PhD 638 PituitaryBlastoma

POSTERIOR PITUITARY NEOPLASMS

642 Pituicytoma, Spindle Cell Oncocytoma, andGranular Cell Tumor of Sella M.BeatrizS. Lopes, MD, PhD

NEURONAL TUMORS

646 Gangliocytoma M.Beatriz S. Lopes,MD, PhD 650 Neuronal Cell Tumors, PituitaryM.Beatriz S. Lopes, MD, PhD

OTHER PITUITARY TUMORS

652 Metastasis toPituitary Gland M.Beatriz S. Lopes,MD, PhD 654 Mesenchymal and HematopoieticTumors, Pituitary Gland M.Beatriz S. Lopes, MD, PhD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITHPRIMARY PITUITARY TUMORS

658 Protocol forExamination of Specimens From Patients WithPrimary Pituitary Tumors Vania Nose, MD, PhD and M.Beatriz S. Lopes, MD, PhD

SECTION 5:

ENDOCRINE PANCREAS

664 Pancreatic Neuroendocrine Neoplasms Vania Nose, MD, PhD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITHCARCINOMA OF ENDOCRINE PANCREAS

674 Pancreatic NeuroendocrineCarcinoma Protocol Vania Nose,MD, PhD

SECTION 6:

ENDOCRINE SKIN

678 Merkel Cell Carcinoma Lori A. Erickson, MD

SECTION 7:

FAMILIAL TUMORSYNDROMES MAJOR ENDOCRINE GLAND AFFECTEDTHYROID GLAND

690 DICER1 Syndrome Vania Nose, MD, PhD and Michelle MenonMiyake, MD 700 Familial ThyroidCarcinoma Vania Nose, MD, PhD 706 McCune-AlbrightSyndrome Vania Nose, MD,PhD 712 Multiple Endocrine Neoplasia Type 2 (MEN2) Vania Nose, MD, PhD720 Nonsyndromic Familial Follicular Cell-Derived Thyroid Carcinoma Vania Nose, MD,PhD 726 PTEN Hamartoma Tumor SyndromesVania Nose, MD, PhD 734 SyndromicFamilial Follicular Cell-Derived Thyroid Carcinoma Vania Nose, MD, PhD

PARATHYROID GLAND

742 Familial IsolatedHyperparathyroidism Vania Nose,MD, PhD and Lori A. Erickson, MD 746 Hyperparathyroidism-JawTumor Syndrome Vania Nose,MD, PhD and Lori A. Erickson, MD 754 MultipleEndocrine Neoplasia Type 1 (MEN1) Vania Nose, MD, PhD and Michelle MenonMiyake, MD 762 Multiple Endocrine Neoplasia Type 4 (MEN4) Vania Nose, MD, PhDand Michelle Menon Miyake, MD

ADRENAL GLAND AND PARAGANGLIA

768 Beckwith-Wiedemann Syndrome Patricia Nogueira de Sa, MD and Vania Nose, MD, PhD 776 Carney Complex Vania Nose, MD, PhD 784 Hereditary Neuroblastoma Vania Nose,MD, PhD 788 Hereditary Paraganglioma/Pheochromocytoma Syndromes Vania Nose, MD, PhD 796 MultipleEndocrine Neoplasia Type 5,MAX-Related Vania Nose, MD, PhD 798 Neurofibromatosis Type1 Michelle Menon Miyake, MD and Vania Nose, MD, PhD 806 von Hippel-Lindau Syndrome Vania Nose, MD, PhD 814 SDH-Deficient Pheochromocytoma and ParagangliomaVania Nose, MD, PhD and Arthur S. Tischler,MD

PANCREAS

820 Glucagon Cell Hyperplasia and Neoplasia Vania Nose,MD, PhD 824 Hereditary and FamilialPancreatic Cancer Syndrome Daniel C. Chung, MD and Vania Nose,MD, PhD 828 MAFA-Related FamilialInsulinomatosis Vania Nose,MD, PhD 830 Pancreatic Neuroendocrine Tumor Syndromes 842 Ectopic (Paraneoplastic) Syndromes Lori A.Erickson, MD