WHO REPORTING SYSTEM FOR LUNG CYTOPAHTOLOGY

DESCRIPTION

The WHOReporting System for Lung Cytopathology is Volume 1 of this new series ofreporting systems for cytopathology, which is a joint project of theInternational Academy of Cytology (IAC) and the International Agency forResearch on Cancer (IARC), a specialized agency of the World HealthOrganization (WHO). The series includes a unique synthesis of the publishedevidence and the practice of cytopathology, and it is linked to the WHOClassification of Tumours series, now in its 5th edition.
Cytopathologists look at tumours slightly differently than other specialistsdo, and there is a need for specialized reporting systems based on the keydiagnostic cytopathological features of tumours, presented in standardizedreports, within a hierarchical system of diagnostic categories. Thesecategories must also be linked to diagnostic management recommendations toimprove communication with clinicians and support patient care. And it isessential that these reporting systems be truly international, to serve the needsof patients worldwide in many differently medically resourced settings.
WHAT ARE THE KEY FEATURES OF THIS FIRST EDITION OF THE SERIES?
These volumes are an essential tool for standardizing diagnostic cytopathologypractice worldwide and will serve as a vehicle for the translation ofcytopathology research into practice. The key diagnostic cytopathologicalfeatures are listed for each tumour type under a defined set of diagnosticcategories and described in precise, uniform language. These diagnostic criteriarepresent the first international consensus and are underpinned by evidencethat has been evaluated and debated by experts in the field. Eachlesion-specific section includes a dedicated subsection discussing thedifferential diagnosis of the cytopathological features that can be usedthroughout the world, including in low-resource settings, followed by asubsection describing the current best-practice application of ancillarytesting (including next-generation sequencing) on cytopathology material.
THIS VOLUME
- Prepared by about 60 authors and editors
- Contributors from around the world, reflecting an international expertise
- More than 300 high-quality images
- More than 1000 references
TABLE OF CONTENTS
1 Introduction to the WHO Reporting System for Lung Cytopathology
Background
The role of lung cytopathology
Diagnostic categories and report structure
Risk of malignancy and management recommendations
2 Lung cytopathology techniques
Sampling methods
FNAB techniques and specimen management
Bronchial wash and bronchial brush techniques and specimen management
Bronchoalveolar lavage techniques and specimen management
Sputum sampling techniques and specimen management
Rapid onsite evaluation
Cell preparation methods
Ancillary testing
Introduction: The role of ancillary testing
Immunocytochemistry
In situ hybridization
Molecular testing
3 Diagnostic category: Insufficient/Inadequate/Non-diagnostic
Introduction
Definition
Discussion and background
Risk of malignancy and management recommendations
Sample reports
4 Diagnostic category: Benign
Introduction
Definition
Discussion and background
Risk of malignancy and management recommendations
Inflammatory processes
Acute inflammation and suppuration
Histiocytic, lymphocytic, and eosinophilic inflammatory patterns
Granulomatous disorders
Inflammatory and reactive changes in glandular cells and squamous cells
Benign neoplastic lesions
Pulmonary hamartoma
Sclerosing pneumocytoma
Solitary tracheobronchial papilloma
Salivary gland neoplasms
PEComa
Spindle cell tumours
Meningiomas
Granular cell tumour
Ectopic thyroid and parathyroid tissues
5 Diagnostic category: Atypical
Introduction
Definition
Discussion and background
Risk of malignancy and management recommendations
Sample reports
6 Diagnostic category: Suspicious for malignancy
Introduction
Definition
Discussion and background
Risk of malignancy and management recommendations
Sample reports
7 Diagnostic category: Malignant
Introduction
Definition
Discussion and background
Risk of malignancy and management recommendations
Specific malignant lesions
Non-small cell carcinomas
Adenocarcinoma of the lung
Squamous cell carcinoma
Non-small cell carcinoma NOS
Other specific carcinomas
Salivary gland-type carcinomas
Adenosquamous carcinoma
Pleomorphic carcinoma
Pulmonary blastoma
Carcinosarcoma
NUT carcinoma
Thoracic SMARCA4-deficient undifferentiated tumour
Neuroendocrine neoplasms
Neuroendocrine tumours
Carcinoid/neuroendocrine tumours of the lung
Neuroendocrine carcinomas
Small cell lung carcinoma
Large cell neuroendocrine carcinoma
Lymphoproliferative diseases
Lymphomas
Pulmonary Langerhans cell histiocytosis
Erdheim-Chester disease
Other malignancies
Spindle cell tumours
Paraganglioma
Diffuse pleural mesothelioma
Primary germ cell tumours of the mediastinum
Primary angiosarcoma of the lung
Pulmonary and thoracic metastases
Sample reports
8 Management recommendations for each diagnostic category
Introduction
Insufficient/Inadequate/Non-diagnostic
Benign
Atypical
Suspicious for malignancy
Malignant
Contributors
Declaration of interests
Sources
References
Subject index