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Withits comprehensive, global coverage of all aspects of diagnosis, screening,and treatment in both adults and children, Firestein & KelleysTextbook of Rheumatology remains your reference of choice in this evolvingfield. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance inrheumatology with an ideal balance of basic science and clinicalapplication. New editors, new chapters, and new illustrations keepyou fully up to date on recent advances in genetics and the microbiome, currenttherapies, and other rapid changes in the field.
TABLE OF CONTENTS
VOLUME I
Part 1: Structureand Function of Bone, Joints, and Connective Tissue
1. Biology of theNormal Joint, 1 Carla R. Scanzello and Steven R.Goldring
2. Synovium, 20 DouglasJ. Veale and Gary S. Firestein
3. Cartilage andChondrocytes, 34 Ali Mobasheri, Mary B.Goldring, and Richard F. Loeser
4. Biology,Physiology, and Morphology of Bone, 60 Aline Bozec,Anika Grüneboom, and Georg Schett
5. Muscle:Anatomy, Physiology, and Biochemistry, 67 Mark S. Miller, Edward P.Debold, and Michael J. Toth
6. Biomechanics,80 Kenton R. Kaufman and KaiNan An
7. RegenerativeMedicine and Tissue Engineering, 92 Frank P. Luyten, Cosimo De Bari, andFrancesco DellAccio
8. Proteinasesand Matrix Degradation, 109 Yoshifumi Itoh
Part 2: CellsInvolved in Autoimmune Diseases and Inflammation
9. DendriticCells, 132 Mansi Saxena, Nicolas Vabret, LucianaRibeiro Muniz, and Nina Bhardwaj
10. MononuclearPhagocytes, 149 Deborah R. Winter, Anna Montgomery, and Harris Perlman
11. Neutrophils,161 Binita Shah, Nathalie Burg, and Michael H. Pillinger
12. TLymphocytes, 182 Ralph C. Budd
13. B Cells,199 Yong-Rui Zou, Christine Grimaldi, and Betty Diamond
14. Fibroblastsand Fibroblast-like Synoviocytes, 222 ChristopherD. Buckley and Andrew Filer
15. Mast Cells,241 Peter A. Nigrovic
16. InnateLymphoid Cells and Natural Killer Cells, 254 Michael A. Paley and Wayne M.Yokoyama
17. Platelets andMegakaryocytes, 262 Eric Boilard and Peter A. Nigrovic
Part 3: EffectorMechanisms in Autoimmunity and Inflammation
18. Principles ofSignaling, 273 Abel Suarez-Fueyo, Vaishali R.Moulton, and George C. Tsokos
19. TheImmunologic Repercussions of Cell Death, 286 Helen M. Beere and Douglas R.Green
20. InnateImmunity, 306 Gregoire Lauvau and Steven A.Porcelli
21. AdaptiveImmunity, 320 Martha S. Jordan and Gary A. Koretzky
22. Autoimmunityand Tolerance, 337 Dwight H. Kono and ArgyriosN. Theofilopoulos
23. TheMicrobiome in Health and Disease, 355 Rob Knight
24. MetabolicRegulation of Immunity, 368 Ruoning Wang,Tingting Wang, and Stephen Tait
25. Genetics ofRheumatic Diseases, 378 Stephen Eyre and Anne Barton
26. Epigeneticsof Rheumatic Diseases, 393 Amr H. Sawalha and Matlock A. Jeffries
27. ComplementSystem, 409 V. Michael Holers and Leendert A. Trouw
28.Prostaglandins, Leukotrienes, and Related Compounds, 420 Robert B. Zurier
29. Chemokinesand Cellular Recruitment, 437 Gerard Graham
30. Angiogenesis,445 Ursula Fearon, Zoltán Szekanecz, and DouglasJ. Veale
31. Cytokines,455 Iain B. McInnes
32. ExperimentalModels for Rheumatoid Arthritis, 467 Rikard Holmdahl
33. NeuronalRegulation of Pain and Inflammation, 480 Camilla I. Svensson and Linda S.Sorkin
Part 4: BroadIssues in the Approach to Rheumatic Disease
34. ClinicalResearch Methods in Rheumatic Disease, 495 Jeffrey R. Curtis, Yvonne M.Golightly, and Kenneth G. Saag
35. EconomicImpact of Arthritis and Rheumatic Conditions, 510 Louise B. Murphy
36. Assessment ofHealth Outcomes, 522 Dorcas E. Beaton, Maarten Boers, Peter Tugwell, andLara Maxwell
37. Biomarkers inRheumatology, 536 Michael J. Townsend, SaloumehK. Fischer, and Andrew C. Chan
38. Occupationaland Recreational Musculoskeletal Disorders, 551 Richard S. Panush
39.Cardiovascular Risk in Inflammatory Rheumatic Disease, 563 Cynthia S.Crowson, Sherine E. Gabriel, and Anne Grete Semb
40. Cancer Riskin Rheumatic Diseases, 579 Eric L. Matteson
41. Introductionto Physical Medicine and Rehabilitation, 592 Sara J. Cuccurullo, JaclynJoki, and Ofure Luke
42. Pregnancy andRheumatic Diseases, 604 Lisa R. Sammaritano andBonnie L. Bermas
Part 5:Evaluation of Generalized and Localized Symptoms
43. History andPhysical Examination of the Musculoskeletal System, 621 John M. Davis III,Kevin G. Moder, and Gene G. Hunder
44. Ultrasound inRheumatology, 638 Eugene Y. Kissin, Paul J. DeMarco, and Amy C. Cannella
45. Evaluation ofMonoarticular and Polyarticular Arthritis, 663 Ronald F. van Vollenhoven
46. Skin andRheumatic Diseases, 678 David F. Fiorentino and Victoria P. Werth
47. The Eye andRheumatic Diseases, 702 James T. Rosenbaum
Part 6:Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain
48. Neck Pain,711 Jennifer Kosty, Rani Nasser, Raul A. Vasquez, Cyrus C. Wong, andJoseph S. Cheng
49. ShoulderPain, 727 Scott David Martin and Thomas S. Thornhill
50. Low BackPain, 753 Rajiv Dixit
51. Hip and KneePain, 776 James I. Huddleston, III, and Stuart Goodman
52. Foot andAnkle Pain, 792 Christopher P. Chiodo, Mark D. Price, and Adam P. Sangeorzan
53. Hand andWrist Pain, 800 Kenneth W. Donohue, Felicity G. Fishman, and Carrie R.Swigart
54.Temporomandibular Joint Pain, 813 Daniel M. Laskin
55. Fibromyalgia,825 Leslie J. Crofford
Part 7:Diagnostic Tests and Procedures in Rheumatic Diseases
56. SynovialFluid Analyses, Synovial Biopsy, and Synovial Pathology, 841 Hani S. El-Gabalawy and Stacy Tanner
57.Arthrocentesis and Injection of Joints and Soft Tissues, 859 Ahmed S.Zayat, Andrea di Matteo, and Richard J. Wakefield
58. Anti-nuclearAntibodies, 875 Stanford L. Peng and Joseph E. Craft
59.Autoantibodies in Rheumatoid Arthritis, 890 Erika Darrah, Antony Rosen,and Felipe Andrade
60. Acute PhaseReactants, 907 Rebecca Haberman, Cesar E. Fors Nieves, Bruce N. Cronstein, and Amit Saxena
61.Imaging in Rheumatic Diseases, 920 Mikkel Østergaard,Ho Jen, Jacob L. Jaremko, and Robert G.W. Lambert
Part 8: Pharmacology of Anti-rheumatic Drugs
62. TherapeuticTargeting of Prostanoids, 965 Leslie J. Crofford
63.Glucocorticoid Therapy, 985 Marlies C. van der Goes and Johannes W.G.Jacobs
64. TraditionalDMARDs: Methotrexate, Lefl, Sulfasalazine,Hydroxychloroquine, and Combination Therapies, 1007 Amy C. Cannella andJames R. ODell
65.Immunosuppressive Drugs, 1031 Jacob M. van Laar
66.Anti-cytokine Therapies, 1046 KatharineMcCarthy, Arthur Kavanaugh, and Christopher T. Ritchlin
67. Cell-TargetedBiologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics,1068 Peter C. Taylor
68.Intra-cellular Targeting Agents in Rheumatic Disease, 1091 Virginia Reddyand Stanley Cohen
69.Urate-Lowering Therapy, 1111 Ted R. Mikuls
70.Bisphosphonates, 1125 Arthur C. Santora II and Kenneth G. Saag
71. AnalgesicAgents in Rheumatic Disease, 1135 Gregory R. Polston and Mark S. Wallace
72. Nutrition andRheumatic Diseases, 1156 Lisa K. Stamp and Leslie G. Cleland
73. Evaluationand Management of Early Undifferentiated Arthritis, 1173 Karim Raza
VOLUME II
Part 9: Rheumatoid Arthritis
74. Etiology ofRheumatoid Arthritis, 1181 Gary S. Firestein
75. Pathogenesisof Rheumatoid Arthritis, 1200 Gary S. Firestein
76. ClinicalFeatures of Rheumatoid Arthritis, 1236 Bryant R. England and Ted R. Mikuls
77. Treatment ofRheumatoid Arthritis, 1258 James R. ODell
78. SjögrensSyndrome, 1284 E. William St. Clair and David L. Leverenz
Part 10: Spondyloarthritis
79. Etiology andPathogenesis of Spondyloarthritis, 1307 Keith A.Sikora and Robert A. Colbert
80. AnkylosingSpondylitis and Other Forms of Axial Spondyloarthritis, 1319 Sjef van der Linden, Matthew Brown, LianneS. Gensler, Tony Kenna, Walter P. Maksymowych, andWilliam J. Taylor
81. ReactiveArthritis, 1344 John D. Carter and Alan P. Hudson
82. PsoriaticArthritis, 1359 Oliver FitzGerald and Conor Magee
83. InflammatoryBowel DiseaseAssociated Arthritis and Other EnteropathicArthropathies, 1381 Richard Zamore, Meenakshi Bewtra,and Alexis Ogdie
Part 11: SystemicLupus Erythematosus and Related Syndromes
84. Etiology andPathogenesis of Systemic Lupus Erythematosus, 1396 Mary K. Crow
85. ClinicalFeatures of Systemic Lupus Erythematosus, 1413 Maria DallEraand David Wofsy
86. Treatment ofSystemic Lupus Erythematosus, 1437 Antonis Fanouriakis,George Bertsias, and Dimitrios T. Boumpas
87.Antiphospholipid Syndrome, 1460 Medha Barbhaiya,Jane E. Salmon, and Doruk Erkan
Part 12: SystemicSclerosis, Inflammatory Myopathies, and Overlap Syndromes
88. Etiology andPathogenesis of Systemic Sclerosis, 1473 John Varga
89. ClinicalFeatures and Treatment of Scleroderma, 1499 Fredrick M. Wigley andFrancesco Boin
90. InflammatoryDiseases of Muscle and Other Myopathies, 1539 KanneboyinaNagaraju, Rohit Aggarwal, and Ingrid E. Lundberg
91. OverlapSyndromes, 1569 Jonathan Graf
Part 13: Vasculitis
92.Classification and Epidemiology of Systemic Vasculitis, 1584 Rennie L.Rhee and Peter A. Merkel
93. Giant CellArteritis, Polymyalgia Rheumatica, and Takayasus Arteritis, 1595 David B.Hellmann
94.Anti-neutrophil Cytoplasmic Antibody Associated Vasculitis, 1617 SharonA. Chung and Paul A. Monach
95. PolyarteritisNodosa and Related Disorders, 1634 Raashid Luqmaniand Abid Awisat
96. ImmuneComplexMediated Small Vessel Vasculitis, 1649 John H. Stone
97. PrimaryAngiitis of the Central Nervous System, 1659 Rula A. Hajj-Ali and Carol A.Langford
98. BehçetsDisease, 1666 Christine S. Ahn, Lindsay C. Strowd, and Joseph L. Jorizzo
Part 14:Crystal-Induced and Inflammasome- Mediated Inflammation
99. Pathogenesisof Inflammasome-Mediated Diseases, 1676 Hal M. Hoffman and Lori Broderick
100. Etiology andPathogenesis of Hyperuricemia and Gout, 1687 Robert T. Keenan, Michael Toprover, and Michael H. Pillinger
101. ClinicalFeatures and Treatment of Gout, 1710 Nicola Dalbeth
102. CalciumCrystal Disease: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate,1732 Robert Terkeltaub
103. FamilialAutoinflammatory Syndromes, 1752 Catharina M. Mulders-Manders, Anna Simon,and Jos W.M. van der Meer
Part 15:Cartilage, Bone, and Heritable Connective Tissue Disorders
104. Pathogenesisof Osteoarthritis, 1770 Paul E. Di Cesare,Dominik R. Haudenschild, Steven B. Abramson, and Jonathan Samuels
105. ClinicalFeatures of Osteoarthritis, 1789 Amanda E. Nelson
106. Treatment ofOsteoarthritis, 1803 Devyani Misra, Deepak Kumar, and Tuhina Neogi
107. MetabolicBone Disease, 1819 Nancy E. Lane
108.Proliferative Bone Diseases, 1839 Reuven Mader
109.Osteonecrosis, 1852 Christopher Chang, Adam Greenspan, and M. EricGershwin
110. RelapsingPolychondritis, 1876 Gaye Cunnane
111. HeritableDiseases of Connective Tissue, 1886 Deborah Krakow
Part 16:Rheumatic Diseases of Childhood
112. Etiology andPathogenesis of Juvenile Idiopathic Arthritis, 1905 Edward M. Behrens
113. ClinicalFeatures and Treatment of Juvenile Idiopathic Arthritis, 1911 Joyce J.Hsu, Tzielan C. Lee, and Christy I. Sandborg
114.Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children,and Neonatal Lupus, 1931 Stacy P. Ardoin and Fatima Barbar-Smiley
115.JuvenileDermatomyositis, Scleroderma, Vasculitis, and Autoimmune Brain Disease, 1942 Angela B. Robinson, JeffreyDvergsten, Kathryn S. Torok, Heather Van Mater, William Gallentine, and Ann M.Reed
Part 17:Infection and Arthritis
116. BacterialArthritis, 1979 Paul P. Cook and Dawd S. Siraj
117. LymeDisease, 1994 Linda K. Bockenstedt
118.Mycobacterial Infections of Bones and Joints, 2009 Eric M. Ruderman andJohn P. Flaherty
119. FungalInfections of Bones and Joints, 2022 Eric M. Ruderman and John P. Flaherty
120. RheumaticManifestations of HIV Infection, 2033 Jonathan Dau and John D. Reveille
121. ViralArthritis, 2048 Philippe Gasque and Xavier Guillot
122. RheumaticFever and Post-streptococcal Arthritis, 2061 Luiza Guilherme, Pedro MingAzevedo, and Jorge Kalil
Part 18:Arthritis Accompanying Systemic Disease
123. Amyloidosis,2077 Helen J. Lachmann and Faye A. Sharpley
124. Sarcoidosis,2088 Peter Korsten, Nadera J. Sweiss, and Robert P. Baughman
125.Hemochromatosis, 2105 Gaye Cunnane
126. HemophilicArthropathy, 2115 Astrid E. Pulles, Lize F. D. van Vulpen,and Floris P.J.G. Lafeber
127. RheumaticManifestations of Hemoglobinopathies, 2127 CarlosJ. Lozada and Elaine C. Tozman
128. IgG4-RelatedDisease, 2135 John H. Stone and Shiv Pillai
129. ArthritisAccompanying Endocrine and Metabolic Disorders, 2149 Sebastian E. Sattui and Joseph A. Markenson
130. Rheumatic Paraneoplastic SyndromesLinks BetweenMalignancy and Autoimmunity, 2161 Bernhard Manger and Georg Schett
131. Tumors andTumor-like Lesions of Joints and Related Structures, 2167 Darcy A. Kerrand Andrew E. Rosenberg
132. AutoimmuneComplications of Immune Checkpoint Inhibitors for Cancer, 2189 Laura C.Cappelli, Clifton O. Bingham III, and Ami A. Shah
Index, I-1
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